Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
Identifieur interne : 000743 ( new/Analysis ); précédent : 000742; suivant : 000744Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
Auteurs : Sriramoju Bharath Kumar [Inde] ; Mettu Ravinder [Inde] ; Golla Kishore [Inde] ; Vaidya Jayathirtha Rao [Inde] ; Perumal Yogeeswari [Inde] ; Darmarajan Sriram [Inde]Source :
- Medicinal Chemistry Research [ 1054-2523 ] ; 2013.
Abstract
Baylis–Hillman adduct-derived
Url:
DOI: 10.1007/s00044-013-0787-x
PubMed: NONE
PubMed Central: 7080103
Affiliations:
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- to stream Main, to step Exploration: 001222
- to stream new, to step Extraction: 000743
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PMC:7080103Le document en format XML
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Bharath" sort="Kumar, Sriramoju Bharath" uniqKey="Kumar S" first="Sriramoju Bharath" last="Kumar">Sriramoju Bharath Kumar</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.417636.1</institution-id><institution-id institution-id-type="ISNI">0000000406361405</institution-id><institution>Crop Protection Chemicals Division,</institution><institution>Indian Institute of Chemical Technology,</institution></institution-wrap>Uppal Road, Hyderabad, 500607 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Uppal Road, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Ravinder, Mettu" sort="Ravinder, Mettu" uniqKey="Ravinder M" first="Mettu" last="Ravinder">Mettu Ravinder</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.417636.1</institution-id><institution-id 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xml:lang="fr">Inde</country><wicri:regionArea>Hyderabad</wicri:regionArea></affiliation></author><author><name sortKey="Jayathirtha Rao, Vaidya" sort="Jayathirtha Rao, Vaidya" uniqKey="Jayathirtha Rao V" first="Vaidya" last="Jayathirtha Rao">Vaidya Jayathirtha Rao</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.417636.1</institution-id><institution-id institution-id-type="ISNI">0000000406361405</institution-id><institution>Crop Protection Chemicals Division,</institution><institution>Indian Institute of Chemical Technology,</institution></institution-wrap>Uppal Road, Hyderabad, 500607 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Uppal Road, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Yogeeswari, Perumal" sort="Yogeeswari, Perumal" uniqKey="Yogeeswari P" first="Perumal" last="Yogeeswari">Perumal Yogeeswari</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.466497.e</institution-id><institution-id institution-id-type="ISNI">0000000417723598</institution-id><institution>Medicinal Chemistry & Antimycobacterial Research Laboratory Group,</institution><institution>Birla Institute of Technology & Science-Pilani,</institution></institution-wrap>Hyderabad, 500078 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Hyderabad</wicri:regionArea></affiliation></author><author><name sortKey="Sriram, Darmarajan" sort="Sriram, Darmarajan" uniqKey="Sriram D" first="Darmarajan" last="Sriram">Darmarajan Sriram</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.466497.e</institution-id><institution-id institution-id-type="ISNI">0000000417723598</institution-id><institution>Medicinal Chemistry & Antimycobacterial Research Laboratory Group,</institution><institution>Birla Institute of Technology & Science-Pilani,</institution></institution-wrap>Hyderabad, 500078 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Hyderabad</wicri:regionArea></affiliation></author></analytic><series><title level="j">Medicinal Chemistry Research</title><idno type="ISSN">1054-2523</idno><idno type="eISSN">1554-8120</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Baylis–Hillman adduct-derived <italic>N</italic>-cinnamyl-substituted isatin derivatives were synthesized and evaluated for their antitubercular activity on <italic>Mycobacterium tuberculosis</italic> H<sub>37</sub>Rv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cell lines: Chinese hamster ovary (CHO cells), Colo 205 (human colon cancer), Sup-T1 (human lymphoma) and C6 glioma (rat glioma) by MTT assay method. The compounds (<bold>3j</bold>–<bold>l</bold>) have shown significant activity against <italic>Mycobacterium</italic> strain and the compound <bold>3l</bold> has shown specific cytotoxic activity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alley, Mc" uniqKey="Alley M">MC Alley</name></author><author><name sortKey="Scudiero, Da" uniqKey="Scudiero D">DA Scudiero</name></author><author><name sortKey="Monks, A" uniqKey="Monks A">A Monks</name></author><author><name sortKey="Hursey, Ml" uniqKey="Hursey M">ML Hursey</name></author><author><name sortKey="Czerwinski, Mj" uniqKey="Czerwinski M">MJ Czerwinski</name></author><author><name sortKey="Fine, Dl" uniqKey="Fine D">DL Fine</name></author><author><name sortKey="Abbott, Bj" uniqKey="Abbott B">BJ Abbott</name></author><author><name sortKey="Mayo, Jg" uniqKey="Mayo J">JG Mayo</name></author><author><name sortKey="Shoemaker, Rh" uniqKey="Shoemaker R">RH 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sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author><author><name sortKey="Yogeeswari, P" uniqKey="Yogeeswari P">P Yogeeswari</name></author><author><name sortKey="Gopal, G" uniqKey="Gopal G">G Gopal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sriram, D" uniqKey="Sriram D">D Sriram</name></author><author><name sortKey="Yogeeswari, P" uniqKey="Yogeeswari P">P Yogeeswari</name></author><author><name sortKey="Meena, K" uniqKey="Meena K">K Meena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Loosdrecht, Aa" uniqKey="Van De Loosdrecht A">AA Van de Loosdrecht</name></author><author><name sortKey="Beelen, Rhj" uniqKey="Beelen R">RHJ Beelen</name></author><author><name sortKey="Ossenkoppele, Gj" uniqKey="Ossenkoppele G">GJ Ossenkoppele</name></author><author><name sortKey="Broekhoven, Mg" uniqKey="Broekhoven M">MG Broekhoven</name></author><author><name sortKey="Langenhuijsen, Mmac" uniqKey="Langenhuijsen M">MMAC Langenhuijsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varma, Rs" uniqKey="Varma R">RS Varma</name></author><author><name sortKey="Nobles, Wl" uniqKey="Nobles W">WL Nobles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varma, Rs" uniqKey="Varma R">RS Varma</name></author><author><name sortKey="Nobles, Wl" uniqKey="Nobles W">WL Nobles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webber, Se" uniqKey="Webber S">SE Webber</name></author><author><name sortKey="Tikhe, J" uniqKey="Tikhe J">J Tikhe</name></author><author><name sortKey="Worland, St" uniqKey="Worland S">ST Worland</name></author><author><name sortKey="Fuhrman, Sa" uniqKey="Fuhrman S">SA Fuhrman</name></author><author><name sortKey="Hendrickson, Tf" uniqKey="Hendrickson T">TF Hendrickson</name></author><author><name sortKey="Matthews, Da" uniqKey="Matthews D">DA Matthews</name></author><author><name sortKey="Love, Ra" uniqKey="Love R">RA Love</name></author><author><name sortKey="Patick, Ak" uniqKey="Patick A">AK Patick</name></author><author><name sortKey="Meador, Jw" uniqKey="Meador J">JW Meador</name></author><author><name sortKey="Ferre, Ra" uniqKey="Ferre R">RA Ferre</name></author><author><name sortKey="Brown, El" uniqKey="Brown E">EL Brown</name></author><author><name sortKey="Delisle, Dm" uniqKey="Delisle D">DM DeLisle</name></author><author><name sortKey="Ford, Ce" uniqKey="Ford C">CE Ford</name></author><author><name sortKey="Binford, Sl" uniqKey="Binford S">SL Binford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Wei, P" uniqKey="Wei P">P Wei</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Pei, J" uniqKey="Pei J">J Pei</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Lai, L" uniqKey="Lai L">L Lai</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Kumar, Sriramoju Bharath" sort="Kumar, Sriramoju Bharath" uniqKey="Kumar S" first="Sriramoju Bharath" last="Kumar">Sriramoju Bharath Kumar</name></noRegion><name sortKey="Jayathirtha Rao, Vaidya" sort="Jayathirtha Rao, Vaidya" uniqKey="Jayathirtha Rao V" first="Vaidya" last="Jayathirtha Rao">Vaidya Jayathirtha Rao</name><name sortKey="Kishore, Golla" sort="Kishore, Golla" uniqKey="Kishore G" first="Golla" last="Kishore">Golla Kishore</name><name sortKey="Ravinder, Mettu" sort="Ravinder, Mettu" uniqKey="Ravinder M" first="Mettu" last="Ravinder">Mettu Ravinder</name><name sortKey="Sriram, Darmarajan" sort="Sriram, Darmarajan" uniqKey="Sriram D" first="Darmarajan" last="Sriram">Darmarajan Sriram</name><name sortKey="Yogeeswari, Perumal" sort="Yogeeswari, Perumal" uniqKey="Yogeeswari P" first="Perumal" last="Yogeeswari">Perumal Yogeeswari</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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